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 BIOGRAPHY |
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Dr. Allison received his Ph.D. from the University of California, Santa Barbara, in 1979 characterizing the mechanism of brain glutamine synthetase. He then joined the laboratory of Dr. Alton Meister at Cornell University Medical College and investigated glutathione and amino acid metabolism. In 1982, he was appointed as a faculty member at the same institution. In 1985, Dr. Allison joined our department. |
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RESEARCH DESCRIPTION |
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Our interests center on amino acid metabolism and, in particular as it relates to glutathione-dependent and glutamine-dependent processes and tyrosination of the cytoskeletal component tubulin. Glutahione is the cheif non-protein thiol in cells, and its multiple roles range form metabolite transport to detoxification processes. Tubulin tyrosination is a unique post-translation covalent modification that may direct cytoskeletal traffic or design. My focus is on the enzymology of these processes and I have a long-term interest in enzyme kinetics, catalysis, and mechanism. |
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