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Molecular Biology
Metabolism and Cell Biology Courses Structural Biology/Advanced Physical Biochemistry Courses Journal Clubs and Seminars Laboratory and other Courses
The courses outlined in Green are also offered through Biochemistry and Molecular Biology as IDP Modules.
 Molecular BiologyBCH 5413 Eukaryotic Molecular Biology and Genetics
3 credits, Fall semester M-W-F, third period This course is designed for graduate or advanced undergraduate students desiring a course in molecular biology beyond an introductory course. Lectures and discussions will emphasize modern molecular and biochemical approaches to solving problems of current interest. NOTE: BCH 5413 replaces BCH 6415, and is a prerequisite for BCH 6415. Students should have a working knowledge of molecular biology such as that covered in "Lehninger's Principles of Biochemistry", third edition; or Mathews and van Holde's "Biochemistry", second edition. We DO NOT recommend this course for students who have not had an introductory course in molecular biology, e.g., BCH 4024 or its equivalents.Room: R2-254 A Coordinator: Philip J. Laipis, Ph.D.(plaipis@ufl.edu )392-6870 BCH 6415 Advanced Molecular and Cell Biology
3 credits, Spring semester M,W,F 5th period An advanced course in the molecular biology of pro- and eukaryotic organisms, with an emphasis on understanding the experimental approaches which have led to recent developments in the field. Topics include chromosome structure and organization, RNA transcription, selected aspects of the molecular regulation of gene expression, protein synthesis and post-translational regulation, DNA synthesis, repair, and recombination. The prerequisites for this course are BCH 5413 or GMS 6001. Students lacking these prerequisites may be admitted with consent of instructor. Room: R 3-295 Coordinator: Thomas P. Yang, Ph.D.(yang@cmg.health.ufl.edu )392-6472 BCH 7410 Advanced Gene Regulation
1 credit, Spring semester This course will served as a literature-based assessment of the most recent advances in factors governing eukaryotic gene regulation. This course will consist of a series of faculty lectures, group discussions and student presentations at the level of original research papers. Room: R3-216B Coordinator: Jorg Bungert, Ph.D.( jbungert@college.med.ufl.edu )392-0121 Metabolism and Cell Biology CoursesBCH 6206 Advanced Metabolism
3 credits, Fall semester M,W,F 2nd Period The reactions of intermediary metabolism with emphasis upon their integration, mechanism. and control. One of the three core departmental courses.Room: R3-216A Coordinator: Susan C. Frost, Ph.D.(sfrost@ufl.edu )392-3207 BCH 6207 Advanced Metabolism:
Role of Membranes in Signal Transduction and Metabolic Control
1 credit, Fall semester M,W,F 2nd period Fundamentals of membrane biochemistry. The course will include discussions of membrane structure, nutrient and ion transport, protein targeting, signal transduction. Students will learn experimental methods and techniques used to gather and analyze data related to membrane biochemistry and its regulation.Room: R3-216A Coordinator: Susan C. Frost, Ph.D.(sfrost@ufl.edu )392-3207 BCH 6208 Advanced Metabolism:
Regulation of Key Reactions in Carbohydrate and Lipid Metabolism
1 credit, Fall semester M,W,F 2nd period Lectures will emphasize key reactions in the metabolic pathways of carbohydrate and lipid metabolism with special attention to the exploration of the experimental basis for our current understanding of these processes. Understanding of the interactions between major metabolic pathways and control of these pathways under different physiological conditions are central themes of the course.Room: R3-216A Coordinator: Susan C. Frost, Ph.D.(sfrost@ufl.edu )392-3207 BCH 6209 Advanced Metabolism:
Regulation of Key Reactions in Amino Acid and Nucleotide Metabolism 1 credit, Fall semester M,W,F 2nd period Lectures will emphasize key reactions in the metabolic pathways of amino acid and nucleotide metabolism with special attention to understanding interactions between major metabolic pathways and control of these pathways under different physiological conditions. Special emphasis will be placed on the structural basis of enzyme function and regulation.Room: R3-216B Coordinator: Susan C. Frost, Ph.D.(sfrost@ufl.edu )392-3207 BCH 6296 Advanced Topics in Metabolic Control 1 credit, Fall semester Discussions of allosteric, hormonal and genetic control of metabolic processes based on readings from the literature.Room: R3-216A Coordinator: Susan C. Frost, Ph.D(sfrost@ufl.edu )392-3207 Structural Biology/Advanced Physical Biochemistry CoursesBCH 6107 Biophysical Techniques in Proteomics and Protein Science 1 credit, Spring Semester M-W-F, 3rd period Theory and application of modern biophysical techniques relevant to proteomics and protein science.Room: LG 179 Coordinator: Robert McKenna(rmckenna@ufl.edu )392-5696 BCH 6740 Structural Biochemistry 3 credits, Spring semester M,T,W,F 3rd period Physical chemistry of biological molecules and the techniques for their study. Constitutes one of the three core departmental courses. This three-part course introduces theoretical and practical aspects of structural biology and biophysical chemistry. The course will be of interest to graduate students and well-prepared undergraduates with interests in biochemistry, molecular and cellular biology, pharmacology, microbiology and cell science, chemistry, physics, plant sciences, and chemical engineering.Room: R3-126 Coordinator: Prof. Daniel L. Purich, Ph.D.(dlpurich@ufl.edu )352-392-1546 BCH 6741C Magnetic Resonance Imaging and Spectroscopy in Living Systems
1-2 credits Fall Semester Lectures: Tuesday, 4th period Lab: Thursday,(last 5 weeks of semester) Lectures will provide a detailed treatment of current MR imaging methods for visualizing the structure of cells, tissues and whole animals with a focus on living systems. Also current in vivo MR spectroscopy methods for monitoring biochemistry in cells suspensions and whole animals will be treated. In addition, a lab will be taught so that the students will have practical experience in sample preparation, operation of the instrumentation, and preliminary data analysis. A student can register for the lecture portion of the course for one-credit hour, or register for the lab portion of the course for one-credit hour, or for both the lecture and lab for two-credit hours. The course objective is to provide the students with the knowledge necessary to apply modern methods of MR imaging and spectroscopy to solve research problems. 15 hours of lectures on MRI and in vivo spectroscopy 15 hour of lab/applicationsRoom: LG-183 Coordinator: Thomas H. Mareci, Ph.D.(thmareci@ufl.edu )392-3375 BCH 6743 Biochemical Energetics
1 credit, Fall semester Wednesday, 8th period This 15 lecture-discussion module will focus on the molecular and structural interpretation of energy transformation in biological systems, including the mechanism of F1F2-type ATP synthase, a biological rotary motor; a proton motive force operating across many energy-conserving biological membrane; molecular chaperones in cytosol, from nascent chain to folded protein; the energy landscape of protein folding, and the role of the thermodynamic molecular switch in biological systems. In the context of these macromolecular interactions, methods of simple thermodynamic analysis will be introduced.Room: MSB 355 Coordinator: Paul W. Chun, Ph.D.(pwchun@biochem.med.ufl.edu )392-3356 BCH 6744 Molecular Structure Determination by X-Ray Crystallography
1 credit Fall Semester Lectures: M-W-F, 4th period The objective of the course is to provide detailed theoretical instructions on the methodology of X-ray crystallography, a biophysical technique at the forefront of research efforts aimed at structure-function elucidation of macromolecules. Students will learn the theory behind the technique of X-ray crystallography and will apply the knowledge obtained to the three-dimensional structure determination of a macromolecule (lysozyme. 15 hours of lectures on X-ray crystallography The anticipation is that students will take both BCH 6744 and BCH 6744L, which will run concurrently. However, students may enroll in either BCH 6744 or BCH 6744L. Room: LG-179 Brain Ins Coordinator: Mavis Agbandje-McKenna(mckenna@ufl.edu )392-5694 BCH 6744L Molecular Structure Determination by X-Ray Crystallography, Laboratory 1 credit Fall semester Lab: Thursdays, 4th thru 6th periods This laboratory class will complement the lectures in BCH 6744. It will provide practical experience in sample preparation, operation of the instrumentation, data acquisition, data analysis, phasing, and refinement. This hands-on approach will reinforce the applicability of this methodology in the analysis of the functional properties of a biological macromolecule. 15 hour of lab/applications. The anticipation is that students will take both BCH 6744 and BCH 6744L, which will run concurrently. However, students may enroll in either BCH 6744 or BCH 6744L.Room: LG-181 Coordinator: Mavis Agbandje-McKenna, Ph.D(mckenna@ufl.edu )392-5694 BCH 6745C Molecular Structure and Dynamics by NMR Spectroscopy 1-2 credits Fall Semester Lectures: M,W,F 4th period Lab: Thursday, 4th, 5th, 6th periods This course is an introduction to modern NMR experiments and their application to biological problems. The class will provide an understanding of multidimensional (2D, 3D, 4D) and multinuclear (1H, 15N, 13C, .. ) NMR experiments. Emphasis will be placed on practical applications of molecular structure and dynamics determination, and extensive use will be made of computer software packages. In the lecture part of the course, students will learn the principles underlying NMR experiments as well as the basic tools to mathematically describe complex NMR experiments. In the laboratory part of the class, students will be trained to use modern NMR instrumentation, data processing, and data analysis. At the end of the laboratory students will have enough training tobe users of the NMR instrumentation in the UF Advanced Magnetic Resonance Imaging and Spectroscopy (AMRIS) facility. 15 hours of lectures on NMR spectroscopy 15 hour of lab/applications Room: LG-198 Coordinator: Arthur S. Edison, Ph.D.(art@mbi.ufl.edu )392-4535 BCH 6746 Structural Biology;Macromolecular Structure, Determination 1 credit, Spring semester M,T,W,F 3rd period This module will provide instruction in experimental approaches to biological macromolecular structure determination, with emphasis on current understanding of protein-protein, protein-nucleic acid structure motifs, dynamics and aspects of protein folding.Room: LG-183 Coordinator: Thomas H. Mareci, Ph.D.(thmareci@ufl.edu )392-3375 BCH 6747 Structural Biology/Advanced Physical Biochemistry:
Spectroscopy and Hydrodynamics
1 credit, Spring semester M,T,W,F 3rd period The first half of the class will focus on the application of spectroscopic techniques (circular dichroism, fluorescence, nuclear magnetic resonance) to determine the structure of biological macromolecules. The second half will cover hydrodynamic approaches including light scattering, molecular diffusion, viscosity and ultracentrifugation. Room: R3-206B Coordinator: Robert J. Cohen, Ph.D.(rjcohen@college.med.ufl.edu )392-4050 BCH 6749C Numerical Methods in Structural Biology 1 credits Summer Provide an overview of mathematical and computational methods needed to understand current structural models, biophysical processes, data acquisition methods, and analysis of data acquired with current methods in structural biology. For students without advanced course work in physical and mathematical methods this course will be taught as a complement to the ?Techniques? courses (BCH 6741C, BCH 6744C and 6745C). The course objective is to provide the students with an overview of mathematical and computational methods necessary to perform complex analysis of biophysical and structural data. Course prerequisite BCH 6740 or equivalent and an undergraduate course in calculus or equivalent. 15 hr of lecture/lab Room: LG-183 Coordinator: Thomas H. Mareci, Ph.D.(thmareci@ufl.edu )392-3375 BCH 7515 Structural Biology/Advanced Physical Biochemistry:
Kinetics and Thermodynamics 1 credit, Spring semester M,T,W,F 3rd period This module will provide the student with the fundamentals of chemical kinetics and thermodynamic analysis of equilibria. The emphasis will be the application of this knowledge to our understanding of basic enzyme kinetics, pulse-chase kinetics, protein polymerization, DNA dynamics, protein-nucleic acid interactions and cooperative ligand binding. Room: R3-126 Coordinator: Daniel L. Purich, Ph.D.(dlpurich@biochem.med.ufl.edu )392-1546 Journal Clubs and SeminarsBCH 6876 Recent Advances in Membrane Biology Journal Club 1 credit, Fall and Spring semesters Literature of membrane biology, presented by students and faculty, discussed in depth. Emphasis is on current developments, data interpretation and critical analysis. Classes are held informally in small groups. Room: R3-216A Coordinator: Susan C. Frost, Ph.D.(sfrost@ufl.edu )392-3207 BCH 6877 Recent Advances in Structural Biology Journal Club
1 credit, Fall and Spring semesters Literature on structural biology, presented by students and faculty, discussed in depth. Emphasis is on current developments, data interpretation and critical analysis. Classes are held informally in small groups. Room: LG-187 Coordinator: Arthur S. Edison, Ph.D.(art@mbi.ufl.edu )392-4535 BCH 6878 Recent Advances in Cytoskeletal Processes Journal Club 1 credit, Fall and Spring semesters Literature on cytoskeletal processes, presented by students and faculty, discussed in depth. Emphasis is on current developments, data interpretation and critical analysis. Classes are held informally in small groups. Room: R3-126 Coordinator: Daniel L. Purich, Ph.D.(dlpurich@biochem.med.ufl.edu )392-1546 BCH 6936 Biochemistry and Molecular Biology Journal Club 1 credit, Fall and Spring semesters Reports and discussions of current research literature given by students and faculty. Room: R3-165 Coordinator: Linda B. Bloom, Ph.D.(lbloom@ufl.edu )392-8708 GMS 5905 Methodologies and discoveries in crystallography and cryo-electron microscopy 1 credit, Spring and Fall semester M 8th period R3-265 Current literature on topics on the methodologies (both theoretical and practical) and the applications and discoveries in the biophysical techniques of crystallography and cryo-electron microscopy are dicussed. Each week a paper is presented by a student or faculty member of the journal club and discussed in depth. Emphasis is on current developments, data interpretation and critical analysis. Classes are held informally in small groups. Room: LG-179 Coordinator: Robert McKenna(rmckenna@ufl.edu )392-5696 Laboratory and other CoursesBCH 6156C Research Methods in Biochemistry 1-4 credits each semester Biochemical research in which the student refines research techniques in physical biochemistry intermediary metabolism, molecular biology and cell biology under the supervision of a staff member. Room: Coordinator: ( ) BCH 6910 Supervised Research 1-5 credits, each semester Open only to departmental graduate students. Room: Coordinator: ( ) |
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